Although ankylosing spondylitis (AS) and the family of related diseases called spondyloarthritis (SpA) primarily affect the spine, other areas of the body can also be involved. Spondyloarthritis does not follow the same course in everyone, even among family members. That said, there are some complications or symptoms that are more common than others. For instance, inflammation of the eye, or iritis, is very common, while neurological symptoms are very rare, and shoulder involvement appears somewhere in the middle. The chronic pain often caused from the inflammation can vary from person to person and range from mild to very severe.
Enthesitis
Inflammation Where the Ligaments Attach to the Bone
Inflammation of the entheses, where joint capsules, ligaments, or tendons attach to bone, is a hallmark of spondyloarthritis (SpA). This can be felt in multiple areas of the body, where doctors can check for pain and tenderness.
The sites are sometimes referred to as “hot spots.” They can lead to swelling and tenderness along the back, pelvic bones, sacroiliac joints, the chest, and the heel. The heel can be significantly affected, and the pain and tenderness can have a serious impact on a person’s mobility. The two areas of the foot that can be affected are the Achilles tendon, at the back of the heel and the plantar fascia, at the base of the heel.
Back and Spine
What Happens over Time
It is the process of healing and repair following inflammation of the entheses that eventually can lead to scarring of the tissues, which subsequently can lead to extra bone formation. Thus, in someone with very severe disease, the process of inflammation can lead, over many years, to a bony fusion of the ligaments in the spine and sometimes in other joints as well, which is called ankylosis. This can cause an increased risk of spinal fracture because of the restricted range of movement and the fact that the bone formed during fusion is inherently weak. Not everyone will go on to this stage of spondylitis.
Fusion of the spine can sometimes lead to a forward curvature of the spine, called kyphosis, causing a forward-stooped posture. Although this can happen in the most severe cases of AS, it is now far less common given the advances in treatment.
It is important to follow your doctor’s instructions, take medicine on schedule, if prescribed, and maintain a daily exercise regimen, which, over time, will lead to better outcomes. It is also important to pay particular attention to your posture in order to reduce the risk of kyphosis. With the advent of biologics, there is reason to believe that the natural course of spondylitis may be slowed or halted. More studies are needed to confirm this.
Hips and Shoulders
The hips and shoulders are affected in about one-third of people with ankylosing spondylitis (AS). Hip involvement usually comes on gradually, and although the pain often is felt in the groin area, it can sometimes be felt in other areas of the body, such as the knees or the front of the thigh. When this happens, it is called “referred pain,” which can be very misleading to both a doctor and affected person. Hip involvement typically is more common in younger people when symptoms first begin. It often carries with it a more severe prognosis or course of disease. Generally speaking, shoulder involvement is mild.
Hips and Shoulders
The hips and shoulders are affected in about one-third of people with ankylosing spondylitis (AS). Hip involvement usually comes on gradually, and although the pain often is felt in the groin area, it can sometimes be felt in other areas of the body, such as the knees or the front of the thigh. When this happens, it is called “referred pain,” which can be very misleading to both a doctor and affected person. Hip involvement typically is more common in younger people when symptoms first begin. It often carries with it a more severe prognosis or course of disease. Generally speaking, shoulder involvement is mild.
The Chest
Adults with spondylitis often have chest pain (costochondritis) that mimics the heavy chest pain of unstable angina (acute heart attack) or pleurisy (the pain with deep breathing that occurs when the outer lining of the lung is inflamed). Anyone experiencing symptoms should seek medical attention to rule out a more serious condition. Over time, long-term inflammation of the joints between the ribs and spine, and where the ribs meet the breastbone in front of the chest, land scarring of tissue results in decreased chest expansion. If the pain is found to be spondylitis-related and you find yourself unable to practice critical deep-breathing exercises, which help maintain chest expansion, there are things that you can do to help yourself:
-Use ice packs on the affected areas for short periods -Try gentle massage of the neck and shoulder area -Try deep breathing exercises after a hot shower or warm bath -Talk to your doctor about trying different medications
Once your doctor has ruled out more serious problems, it might be helpful to take a few sessions with a physical therapist or respiratory therapist, who can provide instructions on how to maximize air intake by learning a technique called “diaphragm breathing.”
Osteoporosis
Spondyloarthritis may affect the structure and strength of bones, making them prone to break under stress.
Spondyloarthritis may affect the structure and strength of bones, making them prone to break under stress.
Very often, MRIs from SpA patients show minimal inflammation in the joint but striking inflammation in the bone next to the joint. This inflammation is also typically seen where ligaments and tendons attach to the bone (enthesitis). If this local inflammation in the spine is not controlled, it will ultimately result in fragile spinal bones.
There is also a second way people with SpA can develop fragile bones. Systemic inflammation causes the release of certain chemicals into the blood that activate cells in bone that can dissolve bone mineral. These cells are called osteoclasts, and secrete acid, which dissolves bone.
As a result, people with SpA suffer from a one-two punch when it comes to bone health. They have inflammation locally within the bones of the spine, but also systemic inflammation contributing to weakening of bones. This is one reason why those with AS are at much higher risk of spinal fractures.
To make matters worse, fusion in the spine, which occurs in some with AS, makes the spine rigid and inflexible, making it more likely to fracture if subjected to any significant impact.
For women with SpA, menopause is an especially precarious period, as the rapid decrease in sex hormone production also results in the activation of osteoclasts.
What can be done about this? First, those with SpA should make sure they stay active, not only to preserve strength and flexibility, but also to preserve bone mineral. The cells that make bone mineral love weight-bearing exercise. But they can only do their work properly if they are supplied with the proper nutrients. This means plenty of vitamin D and calcium each day.
Doctors prefer calcium that is sourced through nutrition, and the recommended amount depends on your age, bone health, and risk factors for osteoporosis. A good rule of thumb is that one good helping of a dairy product – yogurt, cheese, a tall glass of skim milk – provides 300mg of elemental calcium. Other calcium-rich foods include collard greens, and fortified cereals. Doctors also recommend screening for vitamin D deficiency, and consuming the recommended amount of vitamin D daily. Vitamin D is found in foods such as salmon, swordfish, cod liver oil, and fortified foods and beverages. Exposure to sunlight is another source. Numerous vitamin D supplements are also available.
There are several medications available for the treatment of osteoporosis, should you and your doctor determine that they are needed. These include agents belonging to a general class of drugs called bisphosphonates. Biologic medications have also been shown to increase bone density, likely by suppressing inflammation.
The Jaw
About 15 percent of people with spondylitis experience inflammation of the jaw. This can be particularly debilitating, causing difficulty in fully opening the mouth to eat.
Rare Complications
A small percentage of people with long-standing spondylitis may go on to develop rare, but serious complications. This is one of the reasons why it is important for everyone with spondylitis to be checked by a rheumatologist at least once a year. That way, any potentially threatening complications can be caught early and treated before permanent damage has occurred.
Neurological Complications: Cauda Equina Syndrome
Rarely, people with advanced ankylosing spondylitis (AS) may have problems resulting from the scarring of the bundle of nerves at the base of the spine, called cauda equine syndrome. This condition can have a significant impact on a person’s quality of life, and can cause urinary retention and/or incontinence, loss of bowel control, sexual dysfunction, and problems causing pain and weakness of the legs. If you have long-standing AS and are suffering with some of these symptoms, your rheumatologist will be able to refer you to a neurologist for consultation.
The Lungs
Poor chest wall movement may result in decreased vital capacity. Some patients develop scarring or fibrosis at the top of the lungs which detected only by routine chest X-ray (recommended every five years unless there is a special need). Sometimes people have functional lung impairment, which means that it can take longer for colds and other upper respiratory infections to heal. Smoking is absolutely contraindicated in all forms of spondylitis.
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