"This study suggests that fatigue is an important symptom in AS and it seemed to occur in severe AS patients. It should appropriately be measured with respect to its intensity with appropriate measures...Moreover, fatigue may increase functional disability, which is already present as a feature of the disease."

These words come from the study, "Assessment of fatigue in patients with ankylosing spondylitis", that was published in the July issue of the journal, Rheumatology International.

As a follow-up to our November, 2006 article here on Spondylitis.org, "Fatigue In Ankylosing Spondylitis", we would like to bring you a bit more information about fatigue in AS.

The site, Ankylosing Spondylitis Research, has a section summarizing some of the research into AS and fatigue (http://www.asresearch.co.uk/fatigue.htm). It states that 65% of people with AS describe fatigue as a major symptom from time to time. Also, the site states that women are more likely to be affected by fatigue then men. Those with severe disease are also more likely to experience fatigue.

As far as medications that help, it has been found that the anti-TNF drugs appear to reduce fatigue in ankylosing spondylitis.

Fatigue can affect one's desire to do exercise, cause more time away from work, and is linked to less ability to function overall.

What is the cause of fatigue in AS?
Fatigue can be caused by many things related to spondylitis such as loss of sleep because of physical discomfort. But it can also be a by-product of the disease itself.

Spondylitis causes inflammation. When inflammation is present, your body must use energy to deal with it. The release of cytokines(1) during the process of inflammation can produce the sensation of fatigue as well as mild to moderate anemia. Anemia may also contribute to a feeling of tiredness. Treating the inflammation caused by ankylosing spondylitis can assist in decreasing fatigue and anemia. We recommend discussing treatment options with your doctor.

References: Rheumatology International, Volume 27, Number 9, July 2007 , pp. 847-852(6)

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