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Ankylosing spondylitis is known to be highly genetic in nature. The HLA-B27 antigen has been accounted for 20 to 50% of the total genetic risk for this disease, but other genes have been discovered that may lead to susceptibility.
An article published in Joint, Bone & Spine outlines the other genes that may have influence, including:
- IL-1 cluster on chromosome 2
- IL-23R gene on chromosome 1
- ARTS1 genes on chromosome 5 with AS
To read the article summary and view the abstract click here.
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